Combining Foxc2 and Connexin37 deletions in mice leads to severe defects in lymphatic vascular growth and remodeling
Identifieur interne : 001F95 ( Main/Exploration ); précédent : 001F94; suivant : 001F96Combining Foxc2 and Connexin37 deletions in mice leads to severe defects in lymphatic vascular growth and remodeling
Auteurs : John D. Kanady [États-Unis] ; Stephanie J. Munger [États-Unis] ; Marlys H. Witte [États-Unis] ; Alexander M. Simon [États-Unis]Source :
- Developmental biology [ 0012-1606 ] ; 2015.
Descripteurs français
- KwdFr :
- Animaux, Animaux nouveau-nés, Cellules épithéliales (anatomopathologie), Cellules épithéliales (métabolisme), Connexines (déficit), Connexines (métabolisme), Côlon (anatomopathologie), Délétion de gène, Embryon de mammifère (anatomopathologie), Embryon de mammifère (malformations), Facteurs de transcription Forkhead (déficit), Facteurs de transcription Forkhead (métabolisme), Intestin grêle (anatomopathologie), Lymphangiogenèse, Lymphangiome (anatomopathologie), Lymphographie, Malformations crâniofaciales (anatomopathologie), Malformations crâniofaciales (embryologie), Mitose, Mésentère (anatomopathologie), Oedème (anatomopathologie), Peau (anatomopathologie), Peau (embryologie), Plan d'organisation du corps, Souris de lignée C57BL, Vaisseaux lymphatiques (anatomopathologie), Vaisseaux lymphatiques (embryologie), Vaisseaux lymphatiques (malformations).
- MESH :
- anatomopathologie : Cellules épithéliales, Côlon, Embryon de mammifère, Intestin grêle, Lymphangiome, Malformations crâniofaciales, Mésentère, Oedème, Peau, Vaisseaux lymphatiques.
- déficit : Connexines, Facteurs de transcription Forkhead.
- embryologie : Malformations crâniofaciales, Peau, Vaisseaux lymphatiques.
- malformations : Embryon de mammifère, Vaisseaux lymphatiques.
- métabolisme : Cellules épithéliales, Connexines, Facteurs de transcription Forkhead.
- Animaux, Animaux nouveau-nés, Délétion de gène, Lymphangiogenèse, Lymphographie, Mitose, Plan d'organisation du corps, Souris de lignée C57BL.
English descriptors
- KwdEn :
- Animals, Animals, Newborn, Body Patterning, Colon (pathology), Connexins (deficiency), Connexins (metabolism), Craniofacial Abnormalities (embryology), Craniofacial Abnormalities (pathology), Edema (pathology), Embryo, Mammalian (abnormalities), Embryo, Mammalian (pathology), Epithelial Cells (metabolism), Epithelial Cells (pathology), Forkhead Transcription Factors (deficiency), Forkhead Transcription Factors (metabolism), Gene Deletion, Intestine, Small (pathology), Lymphangiogenesis, Lymphangioma (pathology), Lymphatic Vessels (abnormalities), Lymphatic Vessels (embryology), Lymphatic Vessels (pathology), Lymphography, Mesentery (pathology), Mice, Inbred C57BL, Mitosis, Skin (embryology), Skin (pathology).
- MESH :
- chemical , deficiency : Connexins, Forkhead Transcription Factors.
- chemical , metabolism : Connexins, Forkhead Transcription Factors.
- abnormalities : Embryo, Mammalian, Lymphatic Vessels.
- embryology : Craniofacial Abnormalities, Lymphatic Vessels, Skin.
- metabolism : Epithelial Cells.
- pathology : Colon, Craniofacial Abnormalities, Edema, Embryo, Mammalian, Epithelial Cells, Intestine, Small, Lymphangioma, Lymphatic Vessels, Mesentery, Skin.
- Animals, Animals, Newborn, Body Patterning, Gene Deletion, Lymphangiogenesis, Lymphography, Mice, Inbred C57BL, Mitosis.
Abstract
Connexins (Cxs), proteins that are vital for intercellular communication in vertebrates, have recently been shown to play a critical role in lymphatic development. However, our knowledge is currently limited regarding the functional relationships of Cxs with other proteins and signaling pathways. Cell culture studies have shown that Cx37 is necessary for coordinated activation of the transcription factor NFATc1, which cooperates with Foxc2 (another transcription factor) during lymphatic endothelial development. These data suggest that Cxs, Foxc2, and NFATc1 are part of a common developmental pathway. Here, we present a detailed characterization of Foxc2 +/−Cx37 −/− mice, demonstrating that lymphatic network architecture and valve formation rely on the concurrent embryonic expression and function of Foxc2 and Cx37. Foxc2 +/−Cx37−/− mice have lymphedema
Url:
DOI: 10.1016/j.ydbio.2015.06.004
PubMed: 26079578
PubMed Central: 4529811
Affiliations:
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Kanady</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Physiology, University of Arizona, Tucson, AZ 85724, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Physiology, University of Arizona, Tucson, AZ 85724</wicri:regionArea><wicri:noRegion>AZ 85724</wicri:noRegion></affiliation></author><author><name sortKey="Munger, Stephanie J" sort="Munger, Stephanie J" uniqKey="Munger S" first="Stephanie J." last="Munger">Stephanie J. Munger</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Physiology, University of Arizona, Tucson, AZ 85724, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Physiology, University of Arizona, Tucson, AZ 85724</wicri:regionArea><wicri:noRegion>AZ 85724</wicri:noRegion></affiliation></author><author><name sortKey="Witte, Marlys H" sort="Witte, Marlys H" uniqKey="Witte M" first="Marlys H." last="Witte">Marlys H. 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Simon</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Physiology, University of Arizona, Tucson, AZ 85724, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Physiology, University of Arizona, Tucson, AZ 85724</wicri:regionArea><wicri:noRegion>AZ 85724</wicri:noRegion></affiliation></author></analytic><series><title level="j">Developmental biology</title><idno type="ISSN">0012-1606</idno><idno type="eISSN">1095-564X</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Animals, Newborn</term><term>Body Patterning</term><term>Colon (pathology)</term><term>Connexins (deficiency)</term><term>Connexins (metabolism)</term><term>Craniofacial Abnormalities (embryology)</term><term>Craniofacial Abnormalities (pathology)</term><term>Edema (pathology)</term><term>Embryo, Mammalian (abnormalities)</term><term>Embryo, Mammalian (pathology)</term><term>Epithelial Cells (metabolism)</term><term>Epithelial Cells (pathology)</term><term>Forkhead Transcription Factors (deficiency)</term><term>Forkhead Transcription Factors (metabolism)</term><term>Gene Deletion</term><term>Intestine, Small (pathology)</term><term>Lymphangiogenesis</term><term>Lymphangioma (pathology)</term><term>Lymphatic Vessels (abnormalities)</term><term>Lymphatic Vessels (embryology)</term><term>Lymphatic Vessels (pathology)</term><term>Lymphography</term><term>Mesentery (pathology)</term><term>Mice, Inbred C57BL</term><term>Mitosis</term><term>Skin (embryology)</term><term>Skin (pathology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Animaux nouveau-nés</term><term>Cellules épithéliales (anatomopathologie)</term><term>Cellules épithéliales (métabolisme)</term><term>Connexines (déficit)</term><term>Connexines (métabolisme)</term><term>Côlon (anatomopathologie)</term><term>Délétion de gène</term><term>Embryon de mammifère (anatomopathologie)</term><term>Embryon de mammifère (malformations)</term><term>Facteurs de transcription Forkhead (déficit)</term><term>Facteurs de transcription Forkhead (métabolisme)</term><term>Intestin grêle (anatomopathologie)</term><term>Lymphangiogenèse</term><term>Lymphangiome (anatomopathologie)</term><term>Lymphographie</term><term>Malformations crâniofaciales (anatomopathologie)</term><term>Malformations crâniofaciales (embryologie)</term><term>Mitose</term><term>Mésentère (anatomopathologie)</term><term>Oedème (anatomopathologie)</term><term>Peau (anatomopathologie)</term><term>Peau (embryologie)</term><term>Plan d'organisation du corps</term><term>Souris de lignée C57BL</term><term>Vaisseaux lymphatiques (anatomopathologie)</term><term>Vaisseaux lymphatiques (embryologie)</term><term>Vaisseaux lymphatiques (malformations)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="deficiency" xml:lang="en"><term>Connexins</term><term>Forkhead Transcription Factors</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Connexins</term><term>Forkhead Transcription Factors</term></keywords><keywords scheme="MESH" qualifier="abnormalities" xml:lang="en"><term>Embryo, Mammalian</term><term>Lymphatic Vessels</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Cellules épithéliales</term><term>Côlon</term><term>Embryon de mammifère</term><term>Intestin grêle</term><term>Lymphangiome</term><term>Malformations crâniofaciales</term><term>Mésentère</term><term>Oedème</term><term>Peau</term><term>Vaisseaux lymphatiques</term></keywords><keywords scheme="MESH" qualifier="déficit" xml:lang="fr"><term>Connexines</term><term>Facteurs de transcription Forkhead</term></keywords><keywords scheme="MESH" qualifier="embryologie" xml:lang="fr"><term>Malformations crâniofaciales</term><term>Peau</term><term>Vaisseaux lymphatiques</term></keywords><keywords scheme="MESH" qualifier="embryology" xml:lang="en"><term>Craniofacial Abnormalities</term><term>Lymphatic Vessels</term><term>Skin</term></keywords><keywords scheme="MESH" qualifier="malformations" xml:lang="fr"><term>Embryon de mammifère</term><term>Vaisseaux lymphatiques</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Epithelial Cells</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Cellules épithéliales</term><term>Connexines</term><term>Facteurs de transcription Forkhead</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Colon</term><term>Craniofacial Abnormalities</term><term>Edema</term><term>Embryo, Mammalian</term><term>Epithelial Cells</term><term>Intestine, Small</term><term>Lymphangioma</term><term>Lymphatic Vessels</term><term>Mesentery</term><term>Skin</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Animals, Newborn</term><term>Body Patterning</term><term>Gene Deletion</term><term>Lymphangiogenesis</term><term>Lymphography</term><term>Mice, Inbred C57BL</term><term>Mitosis</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Animaux nouveau-nés</term><term>Délétion de gène</term><term>Lymphangiogenèse</term><term>Lymphographie</term><term>Mitose</term><term>Plan d'organisation du corps</term><term>Souris de lignée C57BL</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">Connexins (Cxs), proteins that are vital for intercellular communication in vertebrates, have recently been shown to play a critical role in lymphatic development. However, our knowledge is currently limited regarding the functional relationships of Cxs with other proteins and signaling pathways. Cell culture studies have shown that Cx37 is necessary for coordinated activation of the transcription factor NFATc1, which cooperates with Foxc2 (another transcription factor) during lymphatic endothelial development. These data suggest that Cxs, Foxc2, and NFATc1 are part of a common developmental pathway. Here, we present a detailed characterization of Foxc2 <sup>+/−</sup>Cx37 <sup>−/−</sup> mice, demonstrating that lymphatic network architecture and valve formation rely on the concurrent embryonic expression and function of Foxc2 and Cx37. Foxc2 <sup>+/−</sup>Cx37<sup>−/−</sup> mice have lymphedema <italic>in utero</italic>, exhibit craniofacial abnormalities, show severe dilation of intestinal lymphatics, display abnormal lacteal development, lack lymphatic valves, and typically die perinatally (outcomes not seen in Foxc2 <sup>+/−</sup> or Cx37<sup>−/−</sup> mice separately). We provide a rigorous, quantitative documentation of lymphatic vascular network changes that highlight the specific structural alterations that occur in Foxc2<sup>+/−</sup> Cx37<sup>−/−</sup> mice. These data provide further evidence suggesting that Foxc2 and Cx37 are elements in a common molecular pathway directing lymphangiogenesis.</p></div></front></TEI><affiliations><list><country><li>États-Unis</li></country></list><tree><country name="États-Unis"><noRegion><name sortKey="Kanady, John D" sort="Kanady, John D" uniqKey="Kanady J" first="John D." last="Kanady">John D. Kanady</name></noRegion><name sortKey="Munger, Stephanie J" sort="Munger, Stephanie J" uniqKey="Munger S" first="Stephanie J." last="Munger">Stephanie J. Munger</name><name sortKey="Simon, Alexander M" sort="Simon, Alexander M" uniqKey="Simon A" first="Alexander M." last="Simon">Alexander M. Simon</name><name sortKey="Witte, Marlys H" sort="Witte, Marlys H" uniqKey="Witte M" first="Marlys H." last="Witte">Marlys H. Witte</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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